Phuong-Truc Pham, PhD

Phuong-Truc Pham
Personal Website
Associate Professor, Chemistry
[email protected]
570 963 2564
Dawson, 212F
Penn State Scranton
120 Ridge View Drive
Dunmore, PA 18512
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Discipline Focus: Design and synthesis of organic molecules with biological activities; Design, synthesis and study of materials with electronic properties.

RESEARCH DESCRIPTION

While polymorphism in drugs plays a crucial role in determining their solubility and bioavailability, different polymorphs in organic semiconductors exhibit varied electronic properties.  My research focuses on the design, syntheses and crystal growth of small organic molecules with enhanced and desired properties.

RESEARCH INTEREST

  • Medicinal chemistry
  • Organic materials chemistry
  • Crystal growth and solid-state structures
  • Computational chemistry 

RESEARCH PROJECTS

Syntheses and spectroscopic studies of small organic molecules. Crystal growth of organic materials for x-ray crystallography. Cyclic voltammetric studies of pi-conjugated organic molecules.

  • Pham, P.-T. T., Young, V. G., & Bader, M. (2018). The impact of vinylene bridges and side chain alkyl groups on the solid state structures of tricyanovinyl-substituted thiophenes. CrystEngComm (2018), 20(1), 128-132.
  • Pham, P.-C., Deshmukh, M., & Pham, P.-T. T. (2016). Calcium, phosphorus, magnesium, and Kidney stones. pp. 61-99. Nephrology and Hypertension Board Review.
  • Pham, P.-T. T., & Bader, M. (2014). Inter- and Intramolecular Interactions in Some Bromo- and Tricyano- vinyl-Substituted Thiophenes and Ethylenedioxythiophenes. Crystal Growth & Design, 14, 916-922.
  • Bader, M. M., Pham, P.-T. T., Elandalussee, E. H. (2010) “Dicyanovinyl-Substituted Oligothiophenes.” Crystal Growth and Design, 10(12), 4.
  • Mamoun M. Bader, Phuong-T. Pham, Basant R. Nassar, Hui Lin,Yu Xia, and C. Daniel Frisbie (2009), Extended TCNQ-Based Acceptors: How Molecular Shape and Packing Impact Electron Accepting Behavior, Cryst. Growth Design, 9 (11), pp 4599–4601.
  • Phuong-Truc T. Pham (2009), “Abacavir Methanol 2.5-Solvate”, Acta Cryst., E65, o1937.
  • Phuong-T. T. Pham, Yu Xia, C. Daniel Frisbie, and Mamoun M. Bader (2008). “Single Crystal Field Effect of a Y-Shaped Ladder-Type Oligomer”, J. Phys. Chem. C.,112, 7968-7971.
  • Chun Wang & Phuong-Truc Pham (2008), “Polymers for Viral Gene Delivery”, Expert Opin. Drug Deliv. (2008), 5(4): 1-17.
  • Pham, Phuong-T. and Vince, Robert, (2007). “Carbovir-related compounds and phosphonate analogues”, Phosphorus, Sulfur and Silicon and the Related Elements, 182(4), 779-791.
  • Pham, P.-T. T., Heydrick, S. J., Fox, H. L., Kimball, S.R., Jefferson, Leonard S., Jr., Lynch, C. J. (2000). Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J. of Cell. Bio. 79(3), 427-441.
  • Parker, W. B., Shaddix, S. C, Rose, L. M., Pham, P. T.; Hua, M., Vince, R. (2000). Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells. Nucleosides, Nucleotides & Nucleic Acids. 19(4), 795-804.
  • Fox, H.L., Pham, P. T., Kimball, S. R., Jefferson, L.S., Lynch, C.J. (1998). Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Ame. J. of Phys. 275(5 Pt 1), C1232-8.
  • Vince, Robert, Pham, Phuong T. (1995). The synthesis and biological evaluation of sulfamoyl nucleosides related to carbovir and AZT. Nucleosides & Nucleotides, 14(9 & 10), 2051-60.
  • Wen, Y. D., Remmel, R. P., Pham, P. T., Vince, R., Zimmerman, C. L. (1995). Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats. Pharm. Res. ,12(6), 911-5.
  • Vince, Robert, Kilama, John, Pham, Phuong T. (1995). Beers, Scott A. 6-Substituted derivatives of carbovir: anti-HIV activity. Nucleosides & Nucleotides, 14(8).
  • Bau, R., Pham, P.-T. T., Duncan, G. D., McKenna, C.E. (1995). Absolute Configuration of (+)- [Fluoro(hydroxyphenylphosphinyl)methyl]phosphonic Acid, a specific Inhibitor of Na+-Gradient- Dependent Na+-Phosphate Cotransport across Renal Brush Border Membrane, by X-Ray Crystallographic Analysis of Its (-)-Quinine Salt. J. of Med. Chem., 38(9),1575-8.
  • McKenna, C.E., Pham, P-T.T., Rassier, M. E., Dousa, T.P. (1992). -Halo [(phenylphosphinyl) methyl]phosphonates as specific inhibitors of Na+-gradient-dependent Na+-phosphate cotransport across renal brush border membrane. J. of Med. Chem., 35(26), 4885-92.
  • Ph. D., Chemistry - University of Southern California, Los Angeles, CA
  • B.A., Biochemistry - University of Colorado, Boulder, CO